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zinc finger & BTB domain-containing protein 23; zinc finger protein 336; GDNF-inducible zinc finger protein 1 (GZF1, ZBTB23, ZNF336)
Function:
- transcriptional repressor
- binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3')
- may be regulating VSX2/HOX10 expression
- interacts with NCL
Structure:
- belongs to the krueppel C2H2-type Zn+2-finger protein family
- contains 1 BTB/POZ domain
- contains 10 C2H2-type Zn+2 fingers
Compartment:
- nucleus, nucleoplasm, nucleolus
- nuclear localization depends upon NCL
Expression:
- expressed in adult brain, heart, skeletal muscle, kidney & liver
- also detected in fetal brain & kidney
- expressed at lower levels in fetal lung & liver
- induced by GDNF
General
transcriptional silencer (transcriptional repressor)
Zinc finger & BTB domain containing protein
Properties
SIZE: entity length = 711 aa
MW = 80 kD
COMPARTMENT: cell nucleus
MOTIF: BTB domain {31-103}
MOTIF: Zinc finger
NAME: Zinc finger
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 317-340
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 348-371
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 377-400
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 407-429
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 435-457
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 463-485
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 491-513
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 519-541
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 547-569
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 575-597
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 613842
UniProt Q9H116
PFAM correlations
Entrez Gene 64412
Kegg hsa:64412
References
- UniProt :accession Q9H116
- Entrez Gene :accession 64412