zinc finger protein 335; NRC-interacting factor 1; NIF-1 (ZNF335)

Function: - may regulate transcriptional activation through NCOA6 - phosphorylated upon DNA damage, probably by ATM or ATR - interacts with NCOA6, - does not interact with ligand-bound nuclear hormone receptors, including ESR1, THRA, RARA, RXRA, GCCR or PPARA Structure: - belongs to the krueppel C2H2-type Zn⁺²-finger protein family - contains 13 C2H2-type Zn⁺² fingers Compartment: nucleus Alternative splicing: named isoforms=2 Expression: - expressed in skeletal muscle, thymus, placenta & blood > colon, kidney lung > small intestine, heart, liver, brain

General

C2H2 type zinc finger protein nuclear protein phosphoprotein

Properties

SIZE: entity length = 1342 aa MW = 145 kD COMPARTMENT: cell nucleus MOTIF: Zn finger C2H2-type SITE: 245-268 EFFECTOR-BOUND: Zn+2 Ser phosphorylation site {S416} Zn finger C2H2-type SITE: 465-487 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 495-517 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 523-545 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 562-584 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 590-612 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 621-643 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 649-672 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 678-701 EFFECTOR-BOUND: Zn+2 Ser phosphorylation site {S976} Zn finger C2H2-type SITE: 1019-1041 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 1047-1069 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 1075-1097 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 1103-1126 EFFECTOR-BOUND: Zn+2 Ser phosphorylation site {S1153} glutamine-rich region {1178-1330} MOTIF: glutamine residue (SEVERAL)

Database Correlations

OMIM 610827 UniProt Q9H4Z2 Entrez Gene 63925 Kegg hsa:63925