zinc finger protein 328; zinc finger protein 606 (ZNF606, KIAA1852, ZNF328)

Function: - may act as a transcriptional repressor Structure: - belongs to the krueppel C2H2-type Zn⁺²-finger protein family - contains 16 C2H2-type Zn⁺² fingers - contains 1 KRAB domain Compartment: nucleus Expression: widely expressed in adult & fetal tissues

General

C2H2 type zinc finger protein transcriptional silencer (transcriptional repressor)

Properties

SIZE: entity length = 792 aa MW = 92 kD COMPARTMENT: cell nucleus MOTIF: Krueppel-associated box NAME: Krueppel-associated box SITE: 62-133 MOTIF: KRAB A box KRAB B box EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 289-311 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 317-344 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 400-422 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 428-450 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 456-478 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 484-506 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 512-534 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 540-562 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 568-590 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 596-618 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 624-646 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 652-674 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 680-702 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 708-730 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 736-758 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 764-786 EFFECTOR-BOUND: Zn+2

Database Correlations

OMIM 613905 UniProt Q8WXB4 PFAM correlations Entrez Gene 80095 Kegg hsa:80095