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zinc finger protein 307; zinc finger protein with KRAB & SCAN domains 4; P373c6.1; zinc finger protein 427 (ZKSCAN4, ZNF307, ZNF427)
Function:
- may be involved in the transcriptional activation of MDM2 & EP300 genes
- phosphorylated upon DNA damage, probably by ATM or ATR
Structure:
- belongs to the krueppel C2H2-type Zn+2-finger protein family
- contains 7 C2H2-type Zn+2 fingers
- contains 1 KRAB domain
- contains 1 SCAN box domain
Compartment: nucleus
Expression:
- expressed in adult heart, brain, placenta, lung & kidney, but not in adult liver & skeletal muscle
- in 17-day old embryo, detected in liver, skeletal muscle, brain, heart & small intestine
General
C2H2 type zinc finger protein
nuclear protein
phosphoprotein
Properties
SIZE: entity length = 545 aa
MW = 62 kD
COMPARTMENT: cell nucleus
MOTIF: scan box (LeR) {53-135}
MOTIF: leucine residue (SEVERAL)
Ser phosphorylation site {S165}
Krueppel-associated box
NAME: Krueppel-associated box
SITE: 221-317
MOTIF: KRAB A box
KRAB B box
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 320-342
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 348-370
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 376-398
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 404-426
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 432-454
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 487-509
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 515-537
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 611643
UniProt Q969J2
PFAM correlations
Entrez Gene 387032
Kegg hsa:387032
References
UniProt :accession Q969J2