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zinc finger protein 306; zinc finger protein with KRAB & SCAN domains 3; zinc finger & SCAN domain-containing protein 13; zinc finger protein 309; zinc finger protein 47 homolog; Zf47; Zfp-47 (ZKSCAN3, ZFP47, ZNF306, ZNF309, ZSCAN13)
Function:
- acts as a transcriptional regulator
- binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3'
- associates with chromatin at the ITGB4 & VEGF promoters
Structure:
- belongs to the krueppel C2H2-type Zn+2-finger protein family
- contains 7 C2H2-type Zn+2 fingers
- contains 1 KRAB domain
- contains 1 SCAN box domain
Compartment: nucleus
Expression:
- expressed in colorectal cancers (at protein level)
Pathology:
- activates transcription of genes associated with colon cancer progression
General
C2H2 type zinc finger protein
nuclear protein
Properties
SIZE: entity length = 538 aa
MW = 61 kD
COMPARTMENT: cell nucleus
MOTIF: scan box (LeR) {46-128}
MOTIF: leucine residue (SEVERAL)
Krueppel-associated box
NAME: Krueppel-associated box
SITE: 214-274
MOTIF: KRAB A box
KRAB B box
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 314-336
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 342-364
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 370-392
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 398-420
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 426-448
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 480-502
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 508-530
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 612791
UniProt Q9BRR0
PFAM correlations
Entrez Gene 80317
Kegg hsa:80317
References
- UniProt :accession Q9BRR0
- Entrez Gene :accession 80317