zinc finger protein 300 (ZNF300)

Function: - has transcriptional repressor activity Structure: - belongs to the krueppel C2H2-type Zn⁺²-finger protein family - contains 12 C2H2-type Zn⁺² fingers - contains 1 KRAB domain Compartment: nucleus Alternative splicing: named isoforms=3 Expression: - expressed mostly in heart, skeletal muscle & brain - isoform 1 & isoform 2 are highly expressed in testis

General

transcriptional silencer (transcriptional repressor) zinc finger protein

Properties

SIZE: entity length = 604 aa MW = 69 kD COMPARTMENT: cell nucleus MOTIF: Krueppel-associated box NAME: Krueppel-associated box SITE: 8-79 MOTIF: KRAB A box KRAB B box EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 269-291 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 297-319 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 325-347 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 353-375 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 381-403 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 409-431 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 437-459 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 465-487 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 493-515 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 521-543 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 549-571 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 577-599 EFFECTOR-BOUND: Zn+2

Database Correlations

OMIM 612429 UniProt Q96RE9 Pfam PF01352 Entrez Gene 91975 Kegg hsa:91975