zinc finger protein 295; zinc finger & BTB domain-containing protein 21 (ZNF295, KIAA1227, ZBTB21)

Function: - acts as a transcription repressor - phosphorylated upon DNA damage, probably by ATM or ATR - homodimer, interacts with ZFP161 Structure: - contains 1 BTB/POZ domain - contains 8 C2H2-type Zn⁺² fingers Compartment: nucleus Alternative splicing: named isoforms=2 Expression: ubiquitous in fetal & adult tissues

General

C2H2 type zinc finger protein nuclear protein phosphoprotein

Properties

SIZE: entity length = 1066 aa MW = 119 kD COMPARTMENT: cell nucleus MOTIF: BTB domain {30-96} MOTIF: Zinc finger NAME: Zinc finger EFFECTOR-BOUND: Zn+2 Mediates homodimerization {30-96} Ser phosphorylation site {S361} Ser phosphorylation site {S381} Ser phosphorylation site {S411} Ser phosphorylation site {S413} Ser phosphorylation site {S422} Thr phosphorylation site {T431} Ser phosphorylation site {S434} Ser phosphorylation site {S435} Ser phosphorylation site {S438} Zn finger C2H2-type SITE: 546-569 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 575-598 EFFECTOR-BOUND: Zn+2 Ser phosphorylation site {S605} Zn finger C2H2-type SITE: 670-692 EFFECTOR-BOUND: Zn+2 Ser phosphorylation site {S714} Zn finger C2H2-type SITE: 748-770 EFFECTOR-BOUND: Zn+2 MOTIF: Ser phosphorylation site {S759} Zn finger C2H2-type SITE: 775-798 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 909-932 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 937-959 EFFECTOR-BOUND: Zn+2 Ser phosphorylation site {S983} Ser phosphorylation site {S1003} Thr phosphorylation site {T1005} Zn finger C2H2-type SITE: 1043-1065 EFFECTOR-BOUND: Zn+2

Database Correlations

UniProt Q9ULJ3 PFAM correlations Entrez Gene 49854 Kegg hsa:49854