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zinc finger protein 282; HTLV-I U5RE-binding protein 1; HUB-1 (ZNF282 HUB1)
Function:
- binds to the U5 repressive element (U5RE) of the human T cell leukemia virus type I long terminal repeat
- recognizes the 5'-TCCACCCC-3' sequence as a core motif & exerts a strong repressive effect on HTLV-I LTR-mediated expression
Structure:
- belongs to the krueppel C2H2-type Zn+2-finger protein family
- contains 5 C2H2-type Zn+2 fingers
- contains 1 KRAB domain
Compartment: nucleus (probable)
Expression: ubiquitous
General
C2H2 type zinc finger protein
phosphoprotein
transcriptional silencer (transcriptional repressor)
Properties
SIZE: entity length = 671 aa
MW = 74 kD
COMPARTMENT: cell nucleus
MOTIF: Tyr phosphorylation site {Y161}
Krueppel-associated box
NAME: Krueppel-associated box
SITE: 198-271
MOTIF: KRAB A box
KRAB B box
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 518-540
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 546-568
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 574-596
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 602-624
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 630-652
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 603397
UniProt Q9UDV7
PFAM correlations
Entrez Gene 8427
Kegg hsa:8427
References
- UniProt :accession Q9UDV7
- Entrez Gene :accession 8427