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zinc finger protein 281; GC-box-binding zinc finger protein 1; transcription factor ZBP-99; zinc finger DNA-binding protein 99 (ZNF281, GZP1, ZBP99)
Function:
- role in transcriptional regulation
- represses the transcription of a number of genes including gastrin & ornithine decarboxylase
- binds to the G-rich box in the enhancer region of these genes
- phosphorylated upon DNA damage, probably by ATM or ATR
Structure:
- belongs to the krueppel C2H2-type Zn+2-finger protein family
- contains 4 C2H2-type Zn+2 fingers
Compartment: nucleus
General
C2H2 type zinc finger protein
phosphoprotein
transcriptional silencer (transcriptional repressor)
Properties
SIZE: entity length = 895 aa
MW = 97 kD
COMPARTMENT: cell nucleus
MOTIF: glycine-rich region {4-37}
proline-rich region
SITE: 90-96
MOTIF: proline residue (SEVERAL)
histidine-rich region {141-148}
MOTIF: histidine residue (SEVERAL)
Ser phosphorylation site {S255}
Zn finger C2H2-type
SITE: 261-283
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 289-311
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 317-339
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 345-367
EFFECTOR-BOUND: Zn+2
Ser phosphorylation site {S395}
Ser phosphorylation site {S484}
Ser phosphorylation site {S785}
Ser phosphorylation site {S807}
Database Correlations
UniProt Q9Y2X9
Entrez Gene 23528
Kegg hsa:23528
References
- UniProt :accession Q9Y2X9
- Entrez Gene :accession 23528