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zinc finger protein 274; neurotrophin receptor-interacting factor homolog; zinc finger protein HFB101; zinc finger protein with KRAB & SCAN domains 19; zinc finger protein zfp2; Zf2 (ZNF274, ZKSCAN19, SP2114)
Function:
- probable transcription repressor
- specifically binds to the 3'-end of Zn+2-finger coding genes & recruiting chromatin-modifying proteins such as SETDB1 & TRIM28/KAP1, leading to transcription repression
- interacts with SETDB1 & TRIM28/KAP1
Structure:
- belongs to the krueppel C2H2-type Zn+2-finger protein family
- contains 5 C2H2-type Zn+2 fingers
- contains 2 KRAB domains
- contains 1 SCAN box domain
Compartment:
- cytoplasm (putative)
- nucleus, nucleolus
Alternative splicing: named isoforms=4
General
C2H2 type zinc finger protein
transcriptional silencer (transcriptional repressor)
Properties
SIZE: entity length = 653 aa
MW = 74 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Krueppel-associated box
NAME: Krueppel-associated box
SITE: 14-85
MOTIF: KRAB A box
KRAB B box
EFFECTOR-BOUND: Zn+2
scan box (LeR) {161-243}
MOTIF: leucine residue (SEVERAL)
Krueppel-associated box
NAME: Krueppel-associated box
SITE: 287-360
MOTIF: KRAB A box
KRAB B box
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 507-529
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 535-557
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 563-585
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 591-613
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 619-641
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 605467
UniProt Q96GC6
PFAM correlations
Entrez Gene 10782
Kegg hsa:10782
References
- UniProt :accession Q96GC6
- OMIM :accession 605467
- Entrez Gene :accession 10782