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zinc finger protein 265; zinc finger Ran-binding domain-containing protein 2; zinc finger, splicing (ZRANB2, ZIS, ZNF265)
Function:
- splice factor required for alternative splicing of TRA2B/SFRS10 transcripts
- may interfere with constitutive 5'-splice site selection
- isoform 2 is phosphorylated on Ser-310 upon DNA damage, probably by ATM or ATR
- interacts with the C-terminal half of SNRNP70, the Arg/Ser-rich domain of AKAP17A as well as with U2AF1 & CLK1
Structure:
- the RanBP2-type Zn+2 fingers mediate binding to RNA
- belongs to the ZRANB2 family
- contains 2 RanBP2-type Zn+2 fingers
Compartment: nucleus
Alternative splicing: named isoforms=2
General
nuclear protein
phosphoprotein
zinc finger protein
Properties
SIZE: entity length = 330 aa
MW = 37 kD
COMPARTMENT: cell nucleus
MOTIF: Zinc finger
NAME: Zinc finger
SITE: 9-40
EFFECTOR-BOUND: Zn+2
MOTIF: Ser phosphorylation site {S9}
Zinc finger
NAME: Zinc finger
SITE: 65-94
EFFECTOR-BOUND: Zn+2
Tyr phosphorylation site {Y114}
Ser phosphorylation site {S120}
nuclear targeting {151-324}
MOTIF: Ser phosphorylation site {S153}
Ser phosphorylation site {S181}
Ser phosphorylation site {S188}
Ser phosphorylation site {S193}
arginine/serine-rich region (RS domain) {198-262}
MOTIF: serine residue (SEVERAL)
arginine residue (SEVERAL)
Ser phosphorylation site {S290}
Ser phosphorylation site {S294}
Thr phosphorylation site {T303}
Ser phosphorylation site {S305}
Ser phosphorylation site {S307}
Database Correlations
OMIM 604347
UniProt O95218
Pfam PF00641
Entrez Gene 9406
Kegg hsa:9406
References
- OMIM :accession 604347
- Entrez Gene :accession 9406