zinc finger protein 264 (ZNF264, KIAA0412)

Function: - may be involved in transcriptional regulation - phosphorylated upon DNA damage, probably by ATM or ATR Structure: - belongs to the krueppel C2H2-type Zn+2-finger protein family - contains 13 C2H2-type Zn+2 fingers - contains 1 KRAB domain Compartment: nucleus (probable) Expression: - expressed in kidney, thymus, testis, ovary, brain, lung, placenta, prostate > heart, liver, skeletal muscle, pancreas, spleen, small intestine

General

C2H2 type zinc finger protein nuclear protein phosphoprotein

Properties

SIZE: entity length = 627 aa MW = 71 kD COMPARTMENT: cell nucleus MOTIF: Krueppel-associated box NAME: Krueppel-associated box SITE: 14-85 MOTIF: KRAB A box KRAB B box EFFECTOR-BOUND: Zn+2 Ser phosphorylation site {S80} Zn finger C2H2-type SITE: 203-225 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 231-253 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 259-281 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 287-309 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 315-337 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 343-365 EFFECTOR-BOUND: Zn+2 MOTIF: Tyr phosphorylation site {Y343} Zn finger C2H2-type SITE: 371-393 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 399-421 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 427-449 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 455-477 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 483-505 EFFECTOR-BOUND: Zn+2 MOTIF: Tyr phosphorylation site {Y483} Zn finger C2H2-type SITE: 511-533 EFFECTOR-BOUND: Zn+2 MOTIF: Tyr phosphorylation site {Y511} Zn finger C2H2-type SITE: 539-561 EFFECTOR-BOUND: Zn+2

Database Correlations

OMIM 604668 UniProt O43296 Pfam PF01352 Entrez Gene 9422 Kegg hsa:9422