zinc finger protein 261; zinc finger MYM-type protein 3 (ZMYM3, DXS6673E, KIAA0385, ZNF261)

Function: - role in the regulation of cell morphology & cytoskeletal organization - may be a component of a BHC histone deacetylase complex Structure: - contains 9 MYM-type Zn⁺² fingers Compartment: nucleus (putative) Alternative splicing: named isoforms=2 Expression: - expressed inn brain > muscle, heart > other tissues - not epressed in placenta Pathology: - chromosomal translocation t(X;13)(q13.1;?) involving ZMYM3 may be a cause of X-linked mental retardation

General

nuclear protein phosphoprotein zinc finger protein

Properties

SIZE: entity length = 1370 aa MW = 152 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S263} Ser phosphorylation site {S267} Zinc finger NAME: Zinc finger SITE: 332-366 EFFECTOR-BOUND: Zn+2 Zinc finger NAME: Zinc finger SITE: 378-422 EFFECTOR-BOUND: Zn+2 Zinc finger NAME: Zinc finger SITE: 429-464 EFFECTOR-BOUND: Zn+2 Zinc finger NAME: Zinc finger SITE: 477-511 EFFECTOR-BOUND: Zn+2 Zinc finger NAME: Zinc finger SITE: 521-559 EFFECTOR-BOUND: Zn+2 Zinc finger NAME: Zinc finger SITE: 567-604 EFFECTOR-BOUND: Zn+2 Zinc finger NAME: Zinc finger SITE: 612-646 EFFECTOR-BOUND: Zn+2 Zinc finger NAME: Zinc finger SITE: 653-692 EFFECTOR-BOUND: Zn+2 Zinc finger NAME: Zinc finger SITE: 699-733 EFFECTOR-BOUND: Zn+2 Thr phosphorylation site {T817} Thr phosphorylation site {T826}

Database Correlations

OMIM 300061 UniProt Q14202 PFAM correlations Entrez Gene 9203 Kegg hsa:9203