zinc finger protein 260 (ZNF260, ZFP260)

Function: 1) transcription factor 2) cardiac regulator 3) effector of alpha1-adrenergic signaling 4) binds to PE response elements (PERE) present in promoter of genes such as ANF/NPPA (binds DNA); direct transcriptional activator of NPPA 5) interacts with GATA4, a key cardiac regulator 6) up-regulated by activation of alpha1-adrenergic receptors Structure: 1) belongs to the krueppel C2H2-type zinc-finger protein family. 2) contains 13 C2H2-type zinc fingers Compartment: nucleus

General

C2H2 type zinc finger protein DNA-binding protein

Properties

SIZE: MW = 47 kD entity length = 409 aa COMPARTMENT: cell nucleus MOTIF: Zn finger C2H2-type SITE: 24-46 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 52-74 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 80-102 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 133-155 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 161-183 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 189-211 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 217-239 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 245-267 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 273-295 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 301-323 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 329-351 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 357-379 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 385-407 EFFECTOR-BOUND: Zn+2

Database Correlations

UniProt Q3ZCT1 Pfam PF00096

References

UniProt :accession Q3ZCT1