zinc finger protein 256; bone marrow zinc finger 3; BMZF-3 (ZNF256, BMZF3)

Function: - transcriptional repressor - role in cell proliferation - interacts with TRIM28; requires TRIM28 for its activity Structure: - the KRAB domain mediates interaction with TRIM28 & is required for transcriptional repressor activity - belongs to the krueppel C2H2-type Zn⁺²-finger protein family - contains 15 C2H2-type Zn⁺² fingers - contains 1 KRAB domain Compartment: nucleus Alternative splicing: named isoforms=2 Expression: - induced by GDNF/glial cell line-derived neurotrophic factor

General

C2H2 type zinc finger protein nuclear protein

Properties

SIZE: entity length = 627 aa MW = 72 kD COMPARTMENT: cell nucleus MOTIF: Krueppel-associated box NAME: Krueppel-associated box SITE: 14-96 MOTIF: KRAB A box KRAB B box EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 90-112 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 239-261 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 267-289 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 295-317 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 323-345 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 351-373 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 379-401 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 407-429 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 435-457 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 463-485 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 491-513 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 519-541 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 547-569 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 575-597 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 603-625 EFFECTOR-BOUND: Zn+2

Database Correlations

OMIM 606956 UniProt Q9Y2P7 Pfam PF01352 Entrez Gene 10172 Kegg hsa:10172