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zinc finger protein 24; zinc finger protein 191; zinc finger protein KOX17; retinoic acid suppression protein A; RSG-A; zinc finger & SCAN domain-containing protein 3 (ZNF24, KOX17, ZNF191, ZSCAN3)
Function:
- may function as a transcription factor
- seems to repress transcription
- sumoylated
- phosphorylated upon DNA damage, probably by ATM or ATR
Structure:
- belongs to the krueppel C2H2-type Zn+2-finger protein family
- contains 4 C2H2-type Zn+2 fingers
- contains 1 SCAN box domain
Compartment: nucleus (putative)
Expression: expressed in many tissues except in heart
General
C2H2 type zinc finger protein
phosphoprotein
transcription factor (TF)
zinc finger & SCAN domain-containing protein
Properties
SIZE: entity length = 368 aa
MW = 42 kD
COMPARTMENT: cell nucleus
MOTIF: scan box (LeR) {52-134}
MOTIF: leucine residue (SEVERAL)
Zn finger C2H2-type
SITE: 251-273
EFFECTOR-BOUND: Zn+2
MOTIF: Ser phosphorylation site {S261}
Zn finger C2H2-type
SITE: 279-301
EFFECTOR-BOUND: Zn+2
MOTIF: Tyr phosphorylation site {Y279}
Zn finger C2H2-type
SITE: 307-329
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 335-357
EFFECTOR-BOUND: Zn+2
MOTIF: Tyr phosphorylation site {Y335}
Database Correlations
OMIM 194534
UniProt P17028
PFAM correlations
Entrez Gene 7572
Kegg hsa:7572
References
UniProt :accession P17028