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zinc finger protein 224; bone marrow zinc finger 2; BMZF-2; zinc finger protein 233; zinc finger protein 255; zinc finger protein 27; zinc finger protein KOX22 (ZNF224, BMZF2, KOX22, ZNF233, ZNF255, ZNF27)
Function:
- may be involved in transcriptional regulation as a transcriptional repressor
- interacts with WT1
- interacts with DEPDC1A
Structure:
- belongs to the krueppel C2H2-type Zn+2-finger protein family
- contains 18 C2H2-type Zn+2 fingers
- contains 1 KRAB domain
Compartment:
- nucleus
- colocalizes with DEPDC1A in the nucleus
Expression: ubiquitous. mainly expressed in fetal tissues
Pathology:
- the DEPDC1A-ZNF224 complex may play a role in bladder cancer by repressing transcription of the A20 gene, leading to transport of NF-KB into the nucleus, suppressing apoptosis of bladder cancer cells
General
C2H2 type zinc finger protein
nuclear protein
phosphoprotein
Properties
SIZE: entity length = 707 aa
MW = 82 kD
COMPARTMENT: cell nucleus
MOTIF: Krueppel-associated box
NAME: Krueppel-associated box
SITE: 8-78
MOTIF: KRAB A box
KRAB B box
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 176-198
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 204-226
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 232-254
EFFECTOR-BOUND: Zn+2
MOTIF: Ser phosphorylation site {S245}
Zn finger C2H2-type
SITE: 260-282
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 288-310
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 316-338
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 344-366
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 372-394
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 400-422
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 428-450
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 456-478
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 484-506
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 512-534
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 540-562
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 568-590
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 596-618
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 652-674
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 680-702
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 194555
UniProt Q9NZL3
PFAM correlations
Entrez Gene 7767
Kegg hsa:7767
References
- UniProt :accession Q9NZL3
- Entrez Gene :accession 7767