zinc finger protein 22; zinc finger protein KOX15; Krox-26 protein (ZNF22, KOX15, KROX26)

Function: - binds DNA through the consensus sequence 5'-CAATG-3' - may be involved in transcriptional regulation - may play a role in tooth formation (putative) Structure: -belongs to the krueppel C2H2-type Zn⁺²-finger protein family - contains 5 C2H2-type Zn⁺² fingers Compartment: nucleus (putative) Expression: - in the embryo, expressed in developing craniofacial structures including dental epithelium of maxillary molar tooth organs, tongue epithelium & muscle, & craniofacial bone osteoblasts - in the adult, expressed in mesoderm-derived tissues such as skeletal muscle, heart, kidney & liver > spleen, thymus & brain > endoderm-derived tissues such as intestine & colon

General

C2H2 type zinc finger protein DNA-binding protein

Properties

SIZE: entity length = 224 aa MW = 26 kD COMPARTMENT: cell nucleus MOTIF: Zn finger C2H2-type SITE: 55-77 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 83-105 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 111-133 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 139-161 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 167-189 EFFECTOR-BOUND: Zn+2

Database Correlations

OMIM 194529 UniProt P17026 Pfam PF00096 Entrez Gene 7570 Kegg hsa:7570

References

UniProt :accession P17026