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zinc finger MYM-type protein 2; zinc finger protein 198; fused in myeloproliferative disorders protein; rearranged in atypical myeloproliferative disorder protein (ZMYM2, FIM, RAMP, ZNF198)
Function:
- may function as a transcription factor
- may be a component of a BHC histone deacetylase complex
Structure: contains 9 MYM-type Zn+2 fingers
Compartment: nucleus (putative)
Pathology:
- chromosomal translocation t(8;13)(p11;q12) involving ZMYM2 with FGFR1 may be a cause of stem cell leukemia lymphoma syndrome
General
phosphoprotein
transcription factor (TF)
zinc finger protein
Properties
SIZE: entity length = 1377 aa
MW = 155 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S305}
Zinc finger
NAME: Zinc finger
SITE: 352-386
EFFECTOR-BOUND: Zn+2
MOTIF: Ser phosphorylation site {S362}
Zinc finger
NAME: Zinc finger
SITE: 398-436
EFFECTOR-BOUND: Zn+2
Zinc finger
NAME: Zinc finger
SITE: 445-480
EFFECTOR-BOUND: Zn+2
Zinc finger
NAME: Zinc finger
SITE: 491-549
EFFECTOR-BOUND: Zn+2
Zinc finger
NAME: Zinc finger
SITE: 559-597
EFFECTOR-BOUND: Zn+2
Zinc finger
NAME: Zinc finger
SITE: 605-652
EFFECTOR-BOUND: Zn+2
Zinc finger
NAME: Zinc finger
SITE: 660-694
EFFECTOR-BOUND: Zn+2
Zinc finger
NAME: Zinc finger
SITE: 701-740
EFFECTOR-BOUND: Zn+2
Zinc finger
NAME: Zinc finger
SITE: 747-781
EFFECTOR-BOUND: Zn+2
Ser phosphorylation site {S838}
breakpoint {913-914}
Database Correlations
OMIM 602221
UniProt Q9UBW7
Pfam PF06467
Entrez Gene 7750
Kegg hsa:7750
References
- UniProt :accession Q9UBW7
- Atlas of genetics & cytogenetics in oncology & haematology
http://atlasgeneticsoncology.org/genes/ZNF198ID114.html
Component-of
BHC histone deacetylase complex