zinc finger protein 195 (ZNF195, ZNFP104)

Function: - may be involved in transcriptional regulation Structure: - belongs to the krueppel C2H2-type Zn⁺²-finger protein family - contains 10 C2H2-type Zn⁺² fingers - contains 1 KRAB domain Compartment: nucleus (probable) Alternative splicing: named isoforms=3 Expression: - expressed in adult heart, brain, placenta, skeletal muscle & pancreas, & in fetal lung, kidney & brain - little expression in adult lung, liver & kidney

General

C2H2 type zinc finger protein transcription factor (TF)

Properties

SIZE: entity length = 629 aa MW = 72 kD COMPARTMENT: cell nucleus MOTIF: Krueppel-associated box NAME: Krueppel-associated box SITE: 4-75 MOTIF: KRAB A box KRAB B box EFFECTOR-BOUND: Zn+2 Spacer {76-243} Zn finger C2H2-type SITE: 244-266 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 272-294 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 410-432 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 438-460 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 466-488 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 494-516 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 522-544 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 550-572 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 578-600 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 606-628 EFFECTOR-BOUND: Zn+2

Database Correlations

OMIM 602187 UniProt O14628 PFAM correlations Entrez Gene 7748

References

UniProt :accession O14628