zinc finger protein 189 (ZNF189)

Function: - may be involved in transcriptional regulation Structure: - belongs to the krueppel C2H2-type Zn⁺²-finger protein family - contains 16 C2H2-type Zn⁺² fingers - contains 1 KRAB domain Compartment: nucleus (probable) Alternative splicing: named isoforms=4 Expression: ubiquitous

General

C2H2 type zinc finger protein transcription factor (TF)

Properties

SIZE: entity length = 626 aa MW = 73 kD COMPARTMENT: cell nucleus MOTIF: Krueppel-associated box NAME: Krueppel-associated box SITE: 14-89 MOTIF: KRAB A box KRAB B box EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 148-170 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 176-198 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 204-226 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 232-254 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 260-282 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 288-310 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 316-338 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 344-366 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 372-394 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 400-422 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 456-478 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 484-506 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 512-534 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 540-562 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 568-590 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 599-621 EFFECTOR-BOUND: Zn+2

Database Correlations

OMIM 603132 UniProt O75820 PFAM correlations Entrez Gene 7743 Kegg hsa:7743

References

UniProt :accession O75820