zinc finger protein 180; HHZ168 (ZNF180)

Function: - may be involved in transcriptional regulation - phosphorylated upon DNA damage, probably by ATM or ATR Structure: - belongs to the krueppel C2H2-type Zn⁺²-finger protein family - contains 12 C2H2-type Zn⁺² fingers - contains 1 KRAB domain Compartment: nucleus (probable)

General

C2H2 type zinc finger protein phosphoprotein transcription factor (TF)

Properties

SIZE: entity length = 692 aa MW = 79 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S68} Krueppel-associated box NAME: Krueppel-associated box SITE: 72-145 MOTIF: KRAB A box KRAB B box EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 353-375 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 381-403 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 409-431 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 437-459 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 465-487 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 493-515 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 521-543 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 549-571 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 577-599 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 605-627 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 633-655 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 661-683 EFFECTOR-BOUND: Zn+2

Database Correlations

OMIM 606740 UniProt Q9UJW8 PFAM correlations Entrez Gene 7733 Kegg hsa:7733

References

UniProt :accession Q9UJW8