zinc finger protein 174; AW-1; zinc finger & SCAN domain-containing protein 8 (ZNF174, ZSCAN8)

Function: transcriptional repressor Structure: - belongs to the krueppel C2H2-type Zn⁺²-finger protein family - contains 3 C2H2-type Zn⁺² fingers - contains 1 SCAN box domain Compartment: nucleus Alternative splicing: named isoforms=2 Expression: - expressed in a variety of organs - expressed in adult testis & ovary > small intestine, colon, prostate, thymus, spleen, pancreas, skeletal muscle, heart, brain & kidney - also expressed in umbilical vein endothelial cells, foreskin fibroblast & HEPG2 cells

General

C2H2 type zinc finger protein phosphoprotein transcriptional silencer (transcriptional repressor) zinc finger & SCAN domain-containing protein

Properties

SIZE: entity length = 407 aa MW = 46 kD COMPARTMENT: cell nucleus MOTIF: scan box (LeR) {59-124} MOTIF: leucine residue (SEVERAL) Zn finger C2H2-type SITE: 326-348 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 354-376 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 382-405 EFFECTOR-BOUND: Zn+2 MOTIF: Tyr phosphorylation site {Y382}

Database Correlations

OMIM 603900 UniProt Q15697 PFAM correlations Entrez Gene 7727 Kegg hsa:7727

References

UniProt :accession Q15697