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vascular endothelial zinc finger 1; zinc finger protein 161; transcription factor DB1 (VEZF1, DB1, ZNF161)
Function:
- possible transcription factor
- specifically binds to the CT/GC-rich region of the IL-3 promoter & mediates Tax transactivation of IL-3
- interacts with ARHGAP22 (putative)
Structure:
- belongs to the krueppel C2H2-type Zn+2-finger protein family
- contains 6 C2H2-type Zn+2 fingers
Compartment: nucleus
Expression:
- ubiquitously expressed
- highest levels in skeletal muscle & kidney
General
C2H2 type zinc finger protein
DNA-binding protein
transcription factor (TF)
Properties
SIZE: entity length = 516 aa
MW = 56 kD
COMPARTMENT: cell nucleus
MOTIF: Zn finger C2H2-type
SITE: 74-96
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 174-196
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 202-224
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 232-255
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 261-283
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 287-308
EFFECTOR-BOUND: Zn+2
glutamine-rich region {335-349}
MOTIF: glutamine residue (SEVERAL)
4 X 7 AA repeats of P-[LV]-T-[IL]-T-[ST]- P {389-480}
MOTIF: consensus repeat {389-395}
consensus repeat {440-446}
consensus repeat {452-458}
consensus repeat {474-480}
Database Correlations
OMIM 606747
UniProt Q14119
Pfam PF00096
Entrez Gene 7716
Kegg hsa:7716
References
UniProt :accession Q14119