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zinc finger & BTB domain-containing protein 17; zinc finger protein 60; zinc finger protein 151; Myc-interacting zinc finger protein; Miz-1 (ZBTB17, MIZ1, ZNF151, ZNF60)

Function: - may function as a housekeeping DNA-binding protein that regulates the expression of specific genes - binds to the promoters of adenovirus major late protein & cyclin D1 & activates transcription - has potent growth arrest activity, probably through inhibition of cell cycle progression - required for early embryonic development during gastrulation - binds to the C-terminal helix-loop-helix motif of c-myc which inhibits ZBTB17 transactivation & growth arrest activities & renders it insoluble in the nucleus - c-myc is recruited to the p21WAF1/Cip1 promoter by ZBTB17; this blocks p21WAF1/Cip1 induction by p53 & other activators; c-myc does not affect p53 binding but inhibits bound p53 from activating transcription - interacts with HCFC1, MAGEA4 & TMPRSS11A Structure: - belongs to the krueppel C2H2-type Zn+2-finger protein family - contains 1 BTB/POZ domain - contains 13 C2H2-type Zn+2 fingers Compartment: nucleus Alternative splicing: named isoforms=2

Interactions

molecular events

General

C2H2 type zinc finger protein DNA-binding protein transcription factor (TF) Zinc finger & BTB domain containing protein

Properties

SIZE: entity length = 803 aa MW = 88 kD COMPARTMENT: cell nucleus MOTIF: BTB domain {1-104} MOTIF: Zinc finger NAME: Zinc finger EFFECTOR-BOUND: Zn+2 MYC interaction {269-308} Zn finger C2H2-type SITE: 306-328 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 334-356 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 362-384 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 390-412 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 418-440 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 446-468 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 474-496 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 502-524 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 530-552 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 558-580 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 586-608 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 614-637 EFFECTOR-BOUND: Zn+2 HCFC1 interaction {637-803} MOTIF: MYC interaction {637-718} Zn finger C2H2-type SITE: 717-739 EFFECTOR-BOUND: Zn+2

Database Correlations

OMIM 604084 UniProt Q13105 PFAM correlations Entrez Gene 7709 Kegg hsa:7709

References

  1. UniProt :accession Q13105
  2. Seoane J et al Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage. Nature. 2002 Oct 17;419(6908):729-34. Epub 2002 Oct 2. PMID: 12384701

Component-of

molecular complex