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zinc finger protein OZF; only zinc finger protein; zinc finger protein 146 (ZNF146, OZF)
Function:
- binds DNA.
- interacts with SUMO conjugating enzyme UBC9/UBE2I
- interacts with the telomeric protein TERF2IP
- sumoylated
Structure:
- belongs to the krueppel C2H2-type Zn+2-finger protein family
- contains 10 C2H2-type Zn+2 fingers
Compartment: nucleus
Expression:
- liver, skeletal & heart muscle, mammary cells
- very low levels in brain, lung, placenta & kidney
Pathology:
- strongly overexpressed in many pancreas & colorectal cancers
- increased gene copy numbers are detected in 3 of 12 tumor cell lines & 2 of 12 primary pancreatic carcinomas
- overexpresseed in 80% of colorectal cancers
General
C2H2 type zinc finger protein
DNA-binding protein
Properties
SIZE: entity length = 292 aa
MW = 33 kD
COMPARTMENT: cell nucleus
MOTIF: Zn finger C2H2-type
SITE: 16-38
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 44-66
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 72-94
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 100-122
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 128-150
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 156-178
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 184-206
EFFECTOR-BOUND: Zn+2
TERF2IP interaction {212-292}
MOTIF: Zn finger C2H2-type
SITE: 212-234
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 240-262
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 268-290
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 601505
UniProt Q15072
Pfam PF00096
Entrez Gene 7705
Kegg hsa:7705
References
- UniProt :accession Q15072
- Atlas of genetics & cytogenetics in oncology & haematology
http://atlasgeneticsoncology.org/genes/OZFID267.html