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zinc finger & BTB domain-containing protein 16; zinc finger protein PLZF; promyelocytic leukemia zinc finger protein; zinc finger protein 145 (ZBTB16, PLZF, ZNF145)
Function:
- probable transcription factor
- may play a role in myeloid maturation & in development &/or maintenance of other differentiated tissues
- probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates ubiquitination & subsequent proteasomal degradation of target proteins
- binds EPN1
- interacts with ZBTB32 & CUL3
- protein ubiquitination
Structure:
- belongs to the krueppel C2H2-type Zn+2-finger protein family
- contains 1 BTB (POZ) domain
- contains 9 C2H2-type Zn+2 fingers
Compartment: nucleus
Alternative splicing: named isoforms=2
Expression:
- within the hematopoietic system, PLZF is expressed in bone marrow, early myeloid cell lines & peripheral blood mononuclear cells
- also expressed in the ovary, & at lower levels, in kidney & lung
- induced by retinoic acid
Pathology:
- chromosomal translocation t(11;17)(q32;q21) involving ZBTB16 with RARA may be a cause of acute promyelocytic leukemia
General
C2H2 type zinc finger protein
phosphoprotein
transcription factor (TF)
Zinc finger & BTB domain containing protein
Properties
SIZE: entity length = 673 aa
MW = 74 kD
COMPARTMENT: cell nucleus
MOTIF: BTB domain {34-96}
MOTIF: Zinc finger
NAME: Zinc finger
EFFECTOR-BOUND: Zn+2
Ser phosphorylation site {S76}
Ser phosphorylation site {S184}
Ser phosphorylation site {S197}
Ser phosphorylation site {S256}
Thr phosphorylation site {T282}
breakpoint {394-395}
Zn finger C2H2-type
SITE: 404-426
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 432-454
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 461-483
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 490-512
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 518-540
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 546-568
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 574-596
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 602-624
EFFECTOR-BOUND: Zn+2
Ser phosphorylation site {S628}
Zn finger C2H2-type
SITE: 630-652
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 176797
MORBIDMAP 176797
UniProt Q05516
PFAM correlations
Entrez Gene 7704
Kegg hsa:7704
References
- UniProt :accession Q05516
- Atlas of genetics & cytogenetics in oncology & haematology
http://atlasgeneticsoncology.org/genes/PLZF37.html