zinc finger protein 143; SPH-binding factor (ZNF143, SBF)

Function: - transcriptional activator - binds to the SPH motif of small nuclear RNA (snRNA) gene promoters Structure: - belongs to the GLI C2H2-type Zn⁺²-finger protein family - contains 7 C2H2-type Zn⁺² fingers Compartment: nucleus (putative) Expression: - expressed in all tissues tested - strongest expression in ovary

General

C2H2 type zinc finger protein transcription factor (TF)

Properties

SIZE: entity length = 626 aa MW = 68 kD COMPARTMENT: cell nucleus MOTIF: Zn finger C2H2-type SITE: 225-249 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 255-279 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 285-309 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 315-339 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 345-369 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 375-399 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 405-428 EFFECTOR-BOUND: Zn+2

Database Correlations

OMIM 603433 UniProt P52747 Pfam PF00096 Kegg hsa:7702

References

UniProt :accession P52747