zinc finger protein 141 (ZNF141, D4S90)

Function: - transcriptional repressor (putative) Structure: - belongs to the krueppel C2H2-type Zn⁺²-finger protein family - contains 11 C2H2-type Zn⁺² fingers - contains 1 KRAB domain Compartment: nucleus (putative) Expression: ubiquitously low expression Pathology: - candidate gene for Wolf-Hirschhorn syndrome (4p-)

General

C2H2 type zinc finger protein transcriptional silencer (transcriptional repressor)

Properties

SIZE: entity length = 474 aa MW = 55 kD COMPARTMENT: cell nucleus MOTIF: Krueppel-associated box NAME: Krueppel-associated box SITE: 4-75 MOTIF: KRAB A box KRAB B box EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 171-193 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 199-221 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 227-249 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 255-277 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 283-305 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 311-333 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 339-361 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 367-389 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 395-417 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 423-445 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 451-473 EFFECTOR-BOUND: Zn+2

Database Correlations

OMIM 194648 UniProt Q15928 PFAM correlations Entrez Gene 7700 Kegg hsa:7700

References

UniProt :accession Q15928