zinc finger protein 133; zinc finger protein 150 (ZNF133, ZNF150)

Function: - role as transcriptional repressor (putative) Structure: - belongs to the krueppel C2H2-type Zn⁺²-finger protein family - contains 15 C2H2-type Zn⁺² fingers - contains 1 KRAB domain Compartment: nucleus (putative) Expression: - seems ubiquitous - expressed in the heart, brain, placenta, lung, liver, skeletal muscle, kidney & pancreas

General

C2H2 type zinc finger protein transcriptional silencer (transcriptional repressor)

Properties

SIZE: entity length = 654 aa MW = 73 kD COMPARTMENT: cell nucleus MOTIF: Krueppel-associated box NAME: Krueppel-associated box SITE: 1-72 MOTIF: KRAB A box KRAB B box EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 214-236 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 242-264 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 270-292 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 298-320 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 326-348 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 354-376 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 382-404 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 410-432 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 438-460 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 466-488 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 494-516 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 522-544 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 550-572 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 578-600 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 606-631 EFFECTOR-BOUND: Zn+2

Database Correlations

OMIM 604075 UniProt P52736 PFAM correlations Entrez Gene 7692 Kegg hsa:7692

References

UniProt :accession P52736