zinc finger MIZ domain-containing protein 2; PIAS-like protein Zimp7 (ZMIZ2, KIAA1886, ZIMP7, HRIHFB2007)

Function: - increases ligand-dependent transcriptional activity of AR & other nuclear hormone receptors - interacts with AR, SMARCA4/BRG1 & SMARCE1/BAF57 - interaction with either SMARCA4 or SMARCE1 enhances AR-mediated transcription Structure: - C-terminal proline-rich domain has intrinsic transcriptional activity that is inhibited by N-terminus in the full-length protein - contains 1 SP-RING-type zinc finger Compartment: - nucleus - detected at replication foci throughout S phase Alternative splicing: named isoforms=3 Expression: - expressed in testis > heart, brain, pancreas, prostate, ovary

General

ring finger protein transcription factor (TF)

Properties

SIZE: MW = 97 kD entity length = 920 aa COMPARTMENT: cell nucleus MOTIF: glycine-rich region {47-132} alanine-rich region {147-170} MOTIF: alanine residue (SEVERAL) proline-rich region SITE: 201-403 MOTIF: proline residue (SEVERAL) interaction with AR {435-506} RING-finger {585-662} EFFECTOR-BOUND: Zn+2 FOR-BINDING-OF: DNA motif proline-rich region SITE: 725-906 MOTIF: proline residue (SEVERAL)

Database Correlations

UniProt Q8NF64 Pfam PF02891

References

UniProt :accession Q8NF64