zinc finger matrin-type protein 3 (zinc finger protein WIG-1, p53-activated gene 608 protein, ZMAT3, PAG608, WIG1)

Function: - acts as a bona fide target gene of p53 - may play a role in the p53-dependent growth regulatory pathway - may contribute to p53-mediated apoptosis by regulation of p53 expression & translocation to the nucleus & nucleolus - interacts with dsRNA Structure: contains 3 matrin-type zinc fingers Compartment: nucleus, nucleus, nucleolus Expression: - expressed in adult brain > adult kidney & testis - not detected in fetal brain, heart, pancreas, adrenal gland, liver or small intestine - induced by DNA damage (p53-dependent) - up-regulated following ionizing radiation in primary squamous cell carcinoma of the lung & in various colon cancer cell lines

General

nuclear protein zinc finger protein

Properties

SIZE: entity length = 289 aa MW = 32 kD COMPARTMENT: cell nucleus MOTIF: Zn finger matrin-type NAME: Zn finger matrin-type SITE: 70-100 EFFECTOR-BOUND: Zn+2 Zn finger matrin-type NAME: Zn finger matrin-type SITE: 147-177 EFFECTOR-BOUND: Zn+2 Zn finger matrin-type NAME: Zn finger matrin-type SITE: 246-276 EFFECTOR-BOUND: Zn+2

Database Correlations

OMIM 606452 UniProt Q9HA38

References

UniProt :accession Q9HA38