Search
zinc finger homeobox protein 4 (zinc finger homeodomain protein 4, ZFH-4, ZFHX4)
Function:
- role in neural & muscle differentiation
- role in transcriptional regulation
Structure:
- belongs to the krueppel C2H2-type zinc-finger protein family.
- contains 20 C2H2-type zinc fingers
- contains 4 homeobox DNA-binding domains
Compartment: nucleus
Alternative splicing: named isoforms=3
Expression:
- expressed in brain, skeletal muscle & liver
- very low expression in stomach.
Pathology:
- chromosomal Translocation t(1;8)(p34.3;q21.12) involving ZFHX4 is found in one patient with ptosis
General
C2H2 type zinc finger protein
homeobox protein
transcription factor (TF)
Properties
SIZE: MW = 394 kD
entity length = 3567 aa
COMPARTMENT: cell nucleus
MOTIF: serine-rich region {523-526}
MOTIF: serine residue (SEVERAL)
Zn finger C2H2-type
SITE: 613-636
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 644-667
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 699-723
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 767-789
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 917-941
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 973-995
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 1021-1045
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 1172-1195
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 1201-1224
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 1352-1374
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 1380-1403
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 1496-1522
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 1548-1572
EFFECTOR-BOUND: Zn+2
glutamine-rich region {1644-1793}
MOTIF: glutamine residue (SEVERAL)
Zn finger C2H2-type
SITE: 1901-1924
EFFECTOR-BOUND: Zn+2
proline-rich region
SITE: 1949-2048
MOTIF: proline residue (SEVERAL)
homeodomain
SITE: 2084-2143
homeodomain
SITE: 2181-2240
Zn finger C2H2-type
SITE: 2267-2291
EFFECTOR-BOUND: Zn+2
proline-rich region
SITE: 2345-2429
MOTIF: proline residue (SEVERAL)
Zn finger C2H2-type
SITE: 2448-2470
EFFECTOR-BOUND: Zn+2
homeodomain
SITE: 2560-2619
Zn finger C2H2-type
SITE: 2630-2653
EFFECTOR-BOUND: Zn+2
homeodomain
SITE: 2884-2943
Zn finger C2H2-type
SITE: 2962-2986
EFFECTOR-BOUND: Zn+2
proline-rich region
SITE: 3050-3124
MOTIF: proline residue (SEVERAL)
coiled coil {3265-3294}
Zn finger C2H2-type
SITE: 3354-3378
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 3398-3422
EFFECTOR-BOUND: Zn+2
serine-rich region {3454-3533}
MOTIF: serine residue (SEVERAL)
Database Correlations
UniProt Q86UP3
PFAM correlations
References
UniProt :accession Q86UP3