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zinc finger CCCH domain-containing protein 14 (renal carcinoma antigen NY-REN-37, ZC3H14)
Function:
- binds the polyadenosine RNA oligonucleotides
- phosphorylated upon DNA damage, probably by ATM or ATR
Structure:
- belongs to the ZC3H14 family
- contains 2 C3H1-type Zn+2 fingers
Compartment: nucleus
Alternative splicing: named isoforms=8
General
nuclear protein
phosphoprotein
RNA-binding protein
zinc finger protein
Properties
SIZE: entity length = 736 aa
MW = 83 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S409}
Ser phosphorylation site {S450}
Ser phosphorylation site {S515}
Zinc finger
NAME: Zinc finger
SITE: 596-619
EFFECTOR-BOUND: Zn+2
Zinc finger
NAME: Zinc finger
SITE: 620-640
EFFECTOR-BOUND: Zn+2
MOTIF: Ser phosphorylation site {S620}
Database Correlations
UniProt Q6PJT7
Pfam PF00642
Kegg hsa:7988
References
UniProt :accession Q6PJT7