zinc finger CCCH domain-containing protein 12A (MCP-induced protein 1) (ZC3H12A MCPIP MCPIP1)

Function: - transcriptional activator which triggers apoptosis & promotes angiogenesis in response to the binding of CCL2 to CCR2 - regulates expression of CDH12 & CHD19 Structure: - belongs to the ZC3H12 family - contains 1 C3H1-type Zn⁺² finger Compartment: nucleus Expression: - induced by cytokines (TNF-alpha & interleukin-1) in acute monocytic leukemia cell line THP-1 cells Pathology: - increased expression of ZC3H12A is associated with ischemic heart disease

General

nuclear protein zinc finger protein

Properties

SIZE: entity length = 599 aa MW = 66 kD COMPARTMENT: cell nucleus MOTIF: Zinc finger NAME: Zinc finger SITE: 301-324 EFFECTOR-BOUND: Zn+2 proline-rich region SITE: 458-536 MOTIF: proline residue (SEVERAL)

References

UniProt :accession Q5D1E8