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zinc finger & BTB domain-containing protein 7B; Zfp-67; zinc finger protein Th-POK; T-helper-inducing POZ/Krueppel-like factor; Krueppel-related zinc finger protein cKrox; hcKrox; zinc finger & BTB domain-containing protein 15 (ZBTB7B, ZBTB15, ZFP67, ZNF67)
Function:
1) transcription regulator
2) regulates lineage commitment of immature T-cell precursor
3) necessary & sufficient for commitment of CD4+ cell lineage
4) absence results in CD8+ cell commitment
5) transcriptional repressor of collagen COL1A1 & COL1A2 genes
6) repressor of fibronectin & possibly other extracellular matrix genes (putative)
Structure:
- contains 1 BTB/POZ domain
- contains 4 C2H2-type Zn+2 fingers
Compartment: nucleus
General
transcription factor (TF)
Zinc finger & BTB domain containing protein
Properties
SIZE: MW = 58 kD
entity length = 539 aa
COMPARTMENT: cell nucleus
MOTIF: BTB domain {34-115}
MOTIF: Zinc finger
NAME: Zinc finger
EFFECTOR-BOUND: Zn+2
proline-rich region
SITE: 181-196
MOTIF: proline residue (SEVERAL)
Zn finger C2H2-type
SITE: 346-368
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 374-396
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 402-424
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 430-454
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 607646
UniProt O15156
PFAM correlations
Entrez Gene 7618
References
- Entrez Gene :accession 7618
- UniProt :accession O15156