zinc finger & BTB domain-containing protein 32 (Fanconi anemia zinc finger protein, testis zinc finger protein, FANCC-interacting protein, ZBTB32, FAZF, TZFP)

Function: - DNA-binding protein - binds to 5'-TGTACAGTGT-3' core sequence - may bind CpG islands in association with PLZF - transcriptional transactivator - transcriptional repressor via preventing GATA3 from binding to DNA - role in regulating differentiation & activation of helper T cells - interacts with the N-terminal of FANCC - interacts with ZBTB16 - interacts with GATA3 Structure: - belongs to the krueppel C2H2-type zinc-finger protein family - contains 3 C2H2-type zinc fingers C-terminal zinc finger domain functions as a transcriptional transactivator - contains 1 BTB domain (POZ domain) Compartment: nucleus, located in nuclear speckles Expression: - predominantly expressed in testis - some isoforms are ubiquitously expressed

General

C2H2 type zinc finger protein DNA-binding protein transcription factor (TF)

Properties

SIZE: MW = 53 kD entity length = 487 aa COMPARTMENT: cell nucleus MOTIF: BTB domain {29-87} MOTIF: Zinc finger NAME: Zinc finger EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 373-395 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 401-423 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 428-450 EFFECTOR-BOUND: Zn+2

Database Correlations

OMIM 605859 UniProt Q9Y2Y4 PFAM correlations

References

UniProt :accession Q9Y2Y4