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Zn+2-alpha-2-glycoprotein; Zn-alpha-2-glycoprotein; Zn-alpha-2-GP (AZGP1, ZAG, ZNGP1)
Function:
- stimulates lipid degradation in adipocytes
- may bind polyunsaturated fatty acids
- interacts with PIP
Structure:
- belongs to the MHC class I family
- contains 1 Ig-like C1-type (immunoglobulin-like) domain
Compartment: secreted
Expression:
- blood plasma, seminal plasma, urine, saliva, sweat, epithelial cells of various human glands, liver
Pathology:
- causes extensive fat losses associated with some advanced cancers
- may be associated with reduction of body fat in smokers [2]
General
glycoprotein
metalloprotein
secreted protein
Properties
SIZE: entity length = 295 aa
MW = 34 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-17}
N-glycosylation site {N106}
N-glycosylation site {N109}
cysteine residue {C120}
MODIFICATION: cysteine residue {C183}
N-glycosylation site {N125}
cysteine residue {C183}
MODIFICATION: cysteine residue {C120}
immunoglobulin superfamily domain {204-289}
MOTIF: cysteine residue {C222}
MODIFICATION: cysteine residue {C277}
N-glycosylation site {N256}
cysteine residue {C277}
MODIFICATION: cysteine residue {C222}
Database Correlations
OMIM 194460
UniProt P25311
PFAM correlations
Entrez Gene 563
Kegg hsa:563
References
- UniProt :accession P25311
- Reutrers, May 12, 2009