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zika virus vaccine
Indications:
- prevention of Zika virus infection
Dosage:
- 1 or 2 mg of Zika virus DNA vaccine at baseline, 4 weeks, & 12 weeks [3]
- injections followed by electroporation (use of a pulsed electric field to introduce the DNA into cells) [3]
Mechanism of action:
- whole virus inactivated vaccine
- protein shell is still intact
- can provoke an immune response from host
Comparative biology:
- single dose of DNA vaccine against Zika virus provides protection in rhesus macaques [2]
Related
Zika virus
General
vaccine
References
- NIH News Rekease. Nove 7, 2016
Testing of investigational inactivated Zika vaccine in humans
begins. First of five planned clinical trials to test ZPIV
vaccine.
https://www.nih.gov/news-events/news-releases/testing-investigational-inactivated-zika-vaccine-humans-begins
- Dowd KA, Ko SY, Morabito KM et al.
Rapid development of a DNA vaccine for Zika virus.
Science 2016 Oct 14; 354:237
PMID: 27708058
- Tebas P, Roberts CC, Muthumani K et al
Safety and Immunogenicity of an Anti-Zika Virus DNA Vaccine
- Preliminary Report
N Engl J Med. Oct 4, 2017
PMID: 28976850
http://www.nejm.org/doi/full/10.1056/NEJMoa1708120