YY1-associated factor 2 (YAF2)

Function: 1) binds to MYC & inhibits MYC-mediated transactivation 2) binds to MYCN & enhances MYCN-dependent transcriptional activation 3) increases calpain 2-mediated proteolysis of YY1 in vitro 4) component of the E2F6.com-1 complex 5) interacts with MYC, MYCN, RNF2/RING1B & YY1 Structure: - contains 1 RanBP2-type zinc finger Compartment: nucleus Alternative splicing: named isoforms=2

General

transcriptional silencer (transcriptional repressor) transcription factor (TF) zinc finger protein

Properties

SIZE: MW = 20 kD entity length = 180 aa COMPARTMENT: cell nucleus MOTIF: Zinc finger NAME: Zinc finger SITE: 19-48 EFFECTOR-BOUND: Zn+2

Database Correlations

OMIM 607534 UniProt Q8IY57 Pfam PF00641

References

UniProt :accession Q8IY57