solute carrier family 16 member 2; monocarboxylate transporter 8; MCT 8; X-linked PEST-containing transporter (SLC16A2, MCT8, XPCT)

Function: - very active & specific thyroid hormone transporter - stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) & diidothyronine - does not transport Leu, Phe, Trp or Tyr (putative) Structure: - belongs to the major facilitator superfamily monocarboxylate porter (TC 2.A.1.13) family Compartment: cell membrane Expression: highly expressed in liver & heart Pathology: - defects in SLC16A2 are the cause of monocarboxylate transporter 8 deficiency

General

glycoprotein major facilitator superfamily (MFS) monocarboxylate transporter phosphoprotein solute carrier family 16 (SLC16, SLC16A)

Properties

SIZE: entity length = 539 aa MW = 60 kD COMPARTMENT: cellular membrane MOTIF: cytoplasmic domain {1-96} transmembrane domain {97-117} exoplasmic loop {118-143} transmembrane domain {144-164} cytoplasmic loop {165-171} transmembrane domain {172-192} exoplasmic loop {193-200} MOTIF: Ser phosphorylation site {S193} Ser phosphorylation site {S195} transmembrane domain {201-221} cytoplasmic loop {222-229} transmembrane domain {230-250} exoplasmic loop {251-258} transmembrane domain {259-279} cytoplasmic loop {280-322} transmembrane domain {323-343} exoplasmic loop {344-356} transmembrane domain {357-377} cytoplasmic loop {378-386} transmembrane domain {387-407} exoplasmic loop {408-409} transmembrane domain {410-430} cytoplasmic loop {431-447} transmembrane domain {448-468} exoplasmic loop {469-477} transmembrane domain {478-498} cytoplasmic domain {499-539}

Database Correlations

OMIM correlations MORBIDMAP 300095 UniProt P36021 Pfam PF07690 Kegg hsa:6567