tumor necrosis factor receptor superfamily member 27; X-linked ectodysplasin-A2 receptor; EDA-A2 receptor (EDA2R, TNFRSF27, XEDAR, UNQ2448/PRO5727/PRO34080)

Function: - receptor for EDA isoform A2, but not for EDA isoform A1 - mediates the activation of the NF-kappa-B & JNK pathways - activation seems to be mediated by binding to TRAF3 & TRAF6 - associates with TRAF1, TRAF3 & TRAF6 Structure: contains 3 TNFR-Cys repeats Compartment: membrane Alternative splicing: named isoforms=3

General

glycoprotein tumor necrosis factor [TNF] receptor family

Properties

SIZE: entity length = 297 aa MW = 33 kD COMPARTMENT: plasma membrane MOTIF: TNFR-Cys {2-41} MOTIF: cysteine residue {C3} MODIFICATION: cysteine residue {C15} cysteine residue {C15} MODIFICATION: cysteine residue {C3} cysteine residue {C18} MODIFICATION: cysteine residue {C31} cysteine residue {C21} MODIFICATION: cysteine residue {C41} cysteine residue {C31} MODIFICATION: cysteine residue {C18} cysteine residue {C41} MODIFICATION: cysteine residue {C21} TNFR-Cys {43-83} MOTIF: cysteine residue {C44} MODIFICATION: cysteine residue {C58} cysteine residue {C58} MODIFICATION: cysteine residue {C44} cysteine residue {C61} MODIFICATION: cysteine residue {C75} cysteine residue {C64} MODIFICATION: cysteine residue {C83} N-glycosylation site {N74} cysteine residue {C75} MODIFICATION: cysteine residue {C61} cysteine residue {C83} MODIFICATION: cysteine residue {C64} TNFR-Cys {85-118} MOTIF: cysteine residue {C86} MODIFICATION: cysteine residue {C104} cysteine residue {C104} MODIFICATION: cysteine residue {C86} cysteine residue {C107} MODIFICATION: cysteine residue {C118} cysteine residue {C118} MODIFICATION: cysteine residue {C107} transmembrane domain {139-159}

Database Correlations

OMIM 300276 UniProt Q9HAV5 Pfam PF00020 Kegg hsa:6040

References

UniProt :accession Q9HAV5