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xylosyltransferase 2 (XylT-2, peptide O-xylosyltransferase 1, XYLT2, XT2, UNQ3058/PRO9878)
Functin:
- catalyzes 1st step in biosynthesis of glycosaminoglycan
- transfers D-xylose from UDP-D-xylose to specific Ser of the core protein
- initial enzyme in biosynthesis of chondroitin sulfate & dermatan sulfate proteoglycans in fibroblasts & chondrocytes
- enzyme activity has not been demonstrated
- transfers a beta-D-xylosyl residue from UDP-D-xylose to Ser hydroxy group of an acceptor protein
Cofactor: divalent cations
Structure:
- monomer
- contains disulfide bonds
- belongs to the glycosyltransferase 14 family, XylT subfamily
Compartment:
- endoplasmic reticulum membrane. Golgi membrane
Alternative splicing: named isoforms=2
Expression:
- widely expressed
- xpressed at higher level in kidney & pancreas
General
glycoprotein
glycosyltransferase
membrane protein
Properties
SIZE: MW = 97 kD
entity length = 865 aa
COMPARTMENT: golgi
endoplasmic reticulum
MOTIF: transmembrane domain {16-36}
N-glycosylation site {N122}
N-glycosylation site {N327}
N-glycosylation site {N683}
Database Correlations
OMIM 608125
MORBIDMAP 608125
UniProt Q9H1B5
Pfam PF02485
ENZYME 2.4.2.26
References
- UniProt :accession Q9H1B5
- GGDB, GlycoGene database
http://ggdb.muse.aist.go.jp/GGDB/index.jsp