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Xuebijing (XBJ)
herbal-based intravenous preparation
Indications:
- licensed in 2004 by the National Medical Products Administration (NMPA, China) for treatment of sepsis & multiple organ dysfunction syndrome (septic shock)
- reduces mortality in patients with sepsis
- can prevent the development of organ dysfunction in acute insults.
Mechanism of action:
- Chinese medicine containing extracts from: [2]
- Carthamus tinctorius L. (Carthami Flos, hong hua, Asteraceae)
- Paeonia lactiflora Pall. (Paeoniae radix rubra, chi shao, Ranunculaceae)
- Ligusticum chuanxiong Hort. (Chuanxiong Rhizoma, chuan xiong, Umbelliferae)
- Salvia miltiorrhiza Bge. (Salviae miltiorrhizae Radix Et Rhizoma, dan shen, Labiatae)
- Angelica sinensis (Oliv.) Diels (Angelicae sinensis Radix, dang gui, Umbelliferae)
- antagonistic effect on endotoxin
- inhibitory effect on uncontrolled release of endogenous inflammatory mediators produced by endotoxin-stimulated monocytes/macrophages
- can improve coagulation disorders present in disseminated intravascular coagulation
- can increase activity of superoxide dismutase
- can regulate hypersensitive or hyposensitive immune responses
General
pharmaceutical herb; medicinal herb; herbal supplement; botanical
traditional Chinese medicine (TCM)
pharmacologic combination
References
- Liu S, Yao C, Xie J et al
Effect of an Herbal-Based Injection on 28-Day Mortality in Patients With Sepsis.
The EXIT-SEP Randomized Clinical Trial.
JAMA Intern Med. Published online May 1, 2023
PMID: 37126332
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2804120
- Unger EF, Clissold DB
Xuebijing Injection for the Treatment of Sepsis.
What Would a Path to FDA Approval Look Like?
JAMA Intern Med. Published online May 1, 2023
PMID: 37126325
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2804125
- Li C, Wang P, Li M, Zheng R et al
The current evidence for the treatment of sepsis with Xuebijing injection:
Bioactive constituents, findings of clinical studies and potential mechanisms.
J Ethnopharmacol. 2021 Jan 30;265:113301.
PMID: 32860891 Review