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XP E-correcting protein

Function: - binds specifically to UV-irradiated DNA [1] - also recognizes DNA damage induced by nitrogen mustard, MNNG, 4NQO, 8-methoxypsoralen, cis & trans DDP & apurinic DNA [2] - it is the only XP-correcting protein that is not absolutely required for DNA excision repair in vitro - may also serve another facilitatory role in nucleotide excision repair

Related

XP E-correcting protein gene

General

DNA-binding protein Xeroderma pigmentosum group complementing protein

Properties

COMPARTMENT: cell nucleus MOTIF: DNA-binding motif

Database Correlations

OMIM 278740

References

  1. Lehmann AR. Nucleotide excision repair and the link with transcription. Trends Biochem Sci. 1995 Oct;20(10):402-5. Review. PMID: 8533152
  2. Payne A, Chu G. Xeroderma pigmentosum group E binding factor recognizes a broad spectrum of DNA damage. Mutat Res. 1994 Oct 1;310(1):89-102. PMID: 7523888