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Xpert MTB/RIF assay
Indications:
- assessment of tuberculosis
Procedure:
- turnaround time = 2 hours
Clinical significance:
- can detect active tuberculosis
- can also identify genetic markers that confer resistance to rifampin [1]
Notes:
- use did not reduce long-term TB-related morbidity in Africa [2]
General
laboratory tests for tuberculosis
References
- Physician's First Watch, Julu 29, 2013
David G. Fairchild, MD, MPH, Editor-in-Chief
Massachusetts Medical Society
http://www.jwatch.org
- FDA MedWatch. July 25, 2013
FDA permits marketing of first U.S. test labeled for
simultaneous detection of tuberculosis bacteria and resistance
to the antibiotic rifampin.
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm362602.htm
- Theron G et al
Feasibility, accuracy, and clinical effect of point-of-care
Xpert MTB/RIF testing for tuberculosis in primary-care settings
in Africa: a multicentre, randomised, controlled trial.
The Lancet, Early Online Publication, 28 October 2013
PMID: 24176144
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(13)62073-5/abstract