XP B-correcting protein gene/ERCC-3 selections

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ERCC-3, XP B-correcting protein gene, p89TFIIH gene, haywire or RAD25

Mutant gene in subset of Xeroderma Pigmentosum (XP B) & Cockayne's syndrome. Human homolog of rodent ERCC3, drosophila haywire & yeast RAD25.

Cockayne syndrome TFIIH basal transcription factor complex helicase XPB subunit; basic transcription factor 2 89 kD subunit; BTF2 p89; DNA excision repair protein ERCC-3; DNA repair protein complementing XP-B cells; TFIIH basal transcription factor complex 89 kD subunit; TFIIH 89 kD subunit; TFIIH p89; Xeroderma pigmentosum group B-complementing protein (ERCC3, XPB, XPBC, p89TFIIH) xeroderma pigmentosum

General

unclassified gene

Properties

TEMPLATE-FOR: messenger RNA TEMPLATE-FOR: TFIIH basal transcription factor complex helicase XPB subunit MOTIF: transcription factor binding site transcriptional start site exon intron transcriptional termination site

Database Correlations

OMIM 133510

References

Buratowski S. DNA repair and transcription: the helicase connection. Science. 1993 Apr 2;260(5104):37-8. No abstract available. PMID: 8465198
Schaeffer L, Roy R, Humbert S, Moncollin V, Vermeulen W, Hoeijmakers JH, Chambon P, Egly JM. DNA repair helicase: a component of BTF2 (TFIIH) basic transcription factor. Science. 1993 Apr 2;260(5104):58-63. PMID: 8465201