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Xin actin-binding repeat-containing protein 1 (cardiomyopathy-associated protein 1, XIRP1, CMYA1, XIN)
Function:
- protects actin filaments from depolymerization
- interacts with CTNNB1 (putative)
- interacts with F-actin, FLNC & VASP
Structure:
- Xin repeats bind F-actin
- belongs to the Xin family
- contains 15 Xin repeats
Compartment:
- cell junction
- colocalizes with actin stress fibers
Alternative splicing: named isoforms=3
Expression:
- isoform A, isoform B & isoform C are expressed in heart
Note: 'Xin' means 'heart' in chinese
General
cytoskeletal protein
Properties
SIZE: entity length = 1843 aa
MW = 199 kD
COMPARTMENT: cytoplasm
MOTIF: VASP interaction {1-54}
MOTIF: proline-rich region
SITE: 23-28
MOTIF: proline residue (SEVERAL)
Xin {89-104}
Xin {151-166}
Xin {186-201}
Xin {226-241}
Xin {264-279}
Xin {302-317}
Xin {340-355}
MOTIF: glutamine-rich region {343-346}
MOTIF: glutamine residue (SEVERAL)
Xin {376-391}
Xin {436-451}
Xin {507-522}
CTNNB1 interaction {531-632}
MOTIF: Xin {545-560}
Xin {589-604}
Xin {621-636}
Xin {654-669}
Xin {723-738}
proline-rich region
SITE: 1247-1350
MOTIF: proline residue (SEVERAL)
coiled coil {1462-1490}
FLNC interaction {1685-1843}
Database Correlations
UniProt Q702N8
Pfam PF08043
Kegg hsa:1659
References
UniProt :accession Q702N8