Xenotropic & polytropic retrovirus receptor 1 (protein SYG1 homolog, Xenotropic & polytropic murine leukemia virus receptor X3, X-receptor, XPR1, SYG1, XR)

Function: - may function in G-protein coupled signal transduction (putative) - putative receptor for xenotropic & polytropic murine leukemia retroviruses Structure: - belongs to the SYG1 family - contains 1 SPX domain Compartment: cell membrane Alternative splicing: named isoforms=2 Expression: - widely expressed - detected in spleen, lymph node, thymus, leukocytes, bone marrow, heart, kidney, pancreas & skeletal muscle - expressed in fetal liver Note: - unclear whether its ability to act as a receptor for xenotropic & polytropic murine leukemia retroviruses is relevant in vivo & whether such viruses can infect human

General

phosphoprotein receptor transmembrane 8 protein

Properties

SIZE: entity length = 696 aa MW = 82 kD COMPARTMENT: cellular membrane MOTIF: cytoplasmic domain {1-236} MOTIF: PX domain {1-180} MOTIF: SH3-binding site NAME: SH3-binding site transmembrane domain {237-257} exoplasmic loop {258-264} transmembrane domain {265-285} cytoplasmic loop {286-318} transmembrane domain {319-339} exoplasmic loop {340-345} transmembrane domain {346-368} cytoplasmic loop {369-376} transmembrane domain {377-397} exoplasmic loop {398-402} transmembrane domain {403-423} cytoplasmic loop {424-473} transmembrane domain {474-496} exoplasmic loop {497-507} transmembrane domain {508-528} cytoplasmic domain {529-696} MOTIF: Ser phosphorylation site {S666} Ser phosphorylation site {S668} Thr phosphorylation site {T690}

Database Correlations

OMIM 605237 UniProt Q9UBH6 PFAM correlations Kegg hsa:9213

References

UniProt :accession Q9UBH6