WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif, WWTR1, TAZ)

Function: - transcriptional coactivator - binds to SLC9A3R2 via PDZ motif at plasma membrane - binds to YWHAZ in vivo & in vitro t via phosphoserine-binding motif RSHSSP Structure: - PDZ-binding motif a) essential for stimulated gene transcription b) localizes the protein into both punctate nuclear foci & plasma membrane-associated complexes - contains 1 WW domain - binds to transcription factors via its WW domain Compartment: - nucleus, cytoplasm - concentrates along specific portions of the plasma membrane, & accumulates in punctate nuclear bodies - phosphorylation inhibits transcriptional coactivation via YWHAZ-mediated nuclear export - when phosphorylated, WWTR1 is retained in cytoplasm by YWHAZ Expression: - highly expressed in kidney, heart, placenta, lung

General

phosphoprotein transcription factor (TF)

Properties

SIZE: MW = 44 kD entity length = 400 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: Ser phosphorylation site {S89} WW domain (W/rsp5/WWP domain) {124-157} glutamine-rich region {194-241} MOTIF: glutamine residue (SEVERAL) coiled coil {225-259} PDZ recognition motif NAME: PDZ recognition motif SITE: 394-400 FOR-BINDING-VIA: PDZ domain

Database Correlations

OMIM 607392 UniProt Q9GZV5 Pfam PF00397

References

UniProt :accession Q9GZV5